Subject: Re: next steps
From: "Howard Krein" <[email-masked]>
To: "Yung,W K Alfred" <[email-masked]>
Cc: "Patrick Soon-Shiong" <[email-masked]>, "Mark Hyman" <[email-masked]>, "Hunter Biden" <[email-masked]>, "Hallie Biden" <[email-masked]>, "Beau Biden" <[email-masked]>, "Kim Nicholson" <[email-masked]>, "Phil Yang" <[email-masked]>, "Marci Rodriguez" <[email-masked]>, "Shahrooz Rabizadeh" <[email-masked]>, "Mills,Gordon B" <[email-masked]>, "Hwu,Patrick" <[email-masked]>, "Chin,Lynda" <[email-masked]>, "Cassian Yee" <[email-masked]>, "Shaw,Kenna R" <[email-masked]>, "DePinho,Ronald A" <
Date: Mon, 9 Mar 2015 21:32:58 -0400

Al and Patrick,
As long as tomorrow at 4pm PST (7am Hong Kong) works I will send call in
number for the three of us to connect and further discuss options/plans as
well serve as an introduction.
thanks again and looking forward to speaking with both of you tomorrow
evening.
Warmly,
Howard

On Mon, Mar 9, 2015 at 8:16 PM, Yung,W K Alfred <[email-masked]>
wrote:

>  We have done deep molecular analysis on Beau's original tumor with our
> T200 panel and WGS. The profile is quite bland, not too many mutations is
> found, major GBM associated genes like EGFR, PTEN, PIK3CA, PDGFRA, HER2 are
> negative, only 2 positive hits: p53 and PTPN11. IHC showed increase pAKT,
> PDGFRA, pMAPK. Patrick's team have identified 10 over-expressed peptides
> for the preparation of an immuned-T-cell vaccine which we planned to use
> with the anti-PD1.
> I certainly welcome any help we can get. We have planned to do another
> round of deep molecule analysis of the new tumor after it is removed next
> week.
> Al
>
>
>  W. K. Alfred Yung, M.D.
> Chair,Department of Neuro-Oncology
> UT M.D. Anderson Cancer Center
> 1515 Holcombe Blvd.
> Houston, TX 77030
> 713-794-1285
>
>
>   From: Patrick Soon-Shiong <[email-masked]>
> Date: Monday, March 9, 2015 9:36 AM
> To: Howard Krein <[email-masked]>, Mark Hyman <
> [email-masked]>
> Cc: Hunter Biden <[email-masked]>, Hallie Beiden <[email-masked]>,
> Beau Biden <[email-masked]>, Alfred Yung <[email-masked]>, Kim
> Nicholson <[email-masked]>, Phil Yang <[email-masked]>,
> Marci Rodriguez <[email-masked]>, Shahrooz Rabizadeh <
> [email-masked]>
> Subject: Re: next steps
>
>
>  Dear Howard and Mark
>  Happy to help in anyway we can. As a first step we should retieve the
> tissue (both the paraffin block and the fresh frozen) from the surgery
> performed a year ago. We could begin the panomic sequencing on that sample
> now and before the next surgery. We will look for eGfr and Her+ markers as
> potential targets for the NK92 treatment.
>
>  Kim will reach out to you today. Also will coordinate a call for Tuesday
> with our team to review all images to date
>
>  Keep well
>  Patrick
>  Sent from my BlackB
>  erry 10 smartphone on the Verizon Wireless 4G LTE network.
>    *From: *Howard Krein
> *Sent: *Monday, March 9, 2015 5:36 AM
> *To: *Mark Hyman
> *Cc: *Hunter Biden; Hallie Biden; Beau Biden; Patrick Soon-Shiong; Al
> Yung MD
> *Subject: *Re: next steps
>
>  Mark,
> Thank you once again for arranging this. I had a conversation with Al last
> night and he is on board with everything. He is in Hong Kong till Thursday
> but will be available to do a call with Patrick Tuesday at *4 PM PST* if
> that works. He also realizes the time constraints we are under and doesn't
> want to miss any potential opportunities. I can arrange a call in number if
> that works for Patrick.
> Warmly,
> Howard
>
> Howard D. Krein MD, PhD
> Assistant Professor
>  Div. of Facial Plastics and Reconstructive Surgery
> Dept. of Otolaryngology/ Head and Surgery
> Thomas Jefferson University
> 215-955-6760
>
>  StartUp Health
> Chief Medical Officer
> [email-masked]
>
> On Mar 9, 2015, at 1:41 AM, Mark Hyman <[email-masked]>
> wrote:
>
>   Dear All,
>
>  I am writing to connect everyone so Dr. Patrick can start the process of
> gaining access to records and set up integrated team meeting as the next
> step.
> Thanks for all your time today and allowing us to be part of your care
> team.
> I have also copied Dr. Yung so that he and Dr. Patrick can connect
> directly to expedite care coordination.
>
>  Be well,
>
>  Mark
>  ------------------
> Mark Hyman, MD
> Director, Cleveland Clinic Center for Functional Medicine
> Founder and Medical Director
> The UltraWellness Center
> Chairman, Institute for Functional Medicine
> 55 Pittsfield Road, Suite 9
> Lenox Commons
> Lenox, MA 01240
> (413) 637-9991
> [email-masked]
> www.drhyman.com
>
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-- 
Howard D. Krein MD, PhD
Assistant Professor
Div. of Facial Plastics and Reconstructive Surgery
Dept. of Otolaryngology/ Head and Surgery
Thomas Jefferson University
215-955-6760

Chief Medical Officer -StartUp Health
startuphealth.co